PQQ is recognized as safe. PQQ was administered at 20 mg PQQ/day and 60 mg PQQ/day for four weeks to two groups (10 participants each) of healthy adults given either a PQQ or a placebo. No adverse effect was observed in standard biochemical (e.g., glucose, triglycerides, and various lipoprotein fractions) and functional liver tests (e.g., aspartate aminotransferase and serum glutamic oxaloacetic transaminase) at either dose.
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